CAST · rs6556896
Where this position leads
Condition: Gestational Diabetes Mellitus
Strength of the evidence
Its strongest genetic-study result is p = 10−13, with 1 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 19,445 Finnish ancestry cases, 270,460 Finnish ancestry controls, 19,445 British ancestry cases, 270,460 British ancestry controls, 12,024 Chinese ancestry cases, 67,845 Chinese ancestry controls.
The effect The reported allele is A; the catalogue records no effect size ; p = 2 × 10−13.
Where it sits Chromosome 5, band 5q15 — in an intron of CAST.
rs6556896 is a single position in the genome, in or near the CAST gene. Published research associates it with gestational diabetes mellitus. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Gestational Diabetes Mellitus. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Frontiers in endocrinology 2026, PMID:42109742. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Gestational diabetes mellitus (rs6556896). MyGeneLog™. https://www.mygenelog.com/variants/rs6556896