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Primary biliary cholangitis

RARB · rs6550965

Where this position leads

Condition: Primary Biliary Cholangitis

rs6550965 Condition: Primary Biliary Cholangitis Primary Biliary Cholangitis Condition rs6550965 rs6550965 RARB

What the study found

Who was studied 8,021 European ancestry cases, 16,489 European ancestry controls, 2,495 East Asian ancestry cases, 4,283 East Asian ancestry controls.

The effect Each copy of the A allele shifted the measure 0.152 higher (95% confidence interval 0.11-0.19); p = 1 × 10−14.

Where it sits Chromosome 3, band 3p24.2 — in an intron of RARB.

What each result means

A/A Two copies of the version the research linked to Primary biliary cholangitis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Primary biliary cholangitis. That is a smaller link than two copies.
C/C No copy of the version the research linked to Primary biliary cholangitis. This is the starting point the study compared everyone against.
Source

Questions about rs6550965

What is rs6550965?

rs6550965 is a single position in the genome, in or near the RARB gene. Published research associates it with primary biliary cholangitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6550965 linked to?

On MyGeneLog this position is linked to Primary Biliary Cholangitis. The research behind each link, and its sources, are set out on that condition page.

Does having rs6550965 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6550965 come from?

GWAS Catalog, Journal of hepatology 2021, PMID:34033851. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Primary biliary cholangitis (rs6550965). MyGeneLog™. https://www.mygenelog.com/variants/rs6550965

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