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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
1 / 4
Its strongest genetic-study result is p = 10−12, with 2 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 2,825 African American or Afro-Caribbean cases, 117,425 African American or Afro-Caribbean controls, 22,049 European ancestry cases, 419,651 European ancestry controls, 1,071 Hispanic or Latin American cases, 58,194 Hispanic or Latin American controls.
The effect
Each copy of the T allele shifted the measure 0.113 lower (95% confidence interval 0.085-0.14); p = 2 × 10−12.
How common The T allele had a frequency of about 90% in the people studied.
Where it sits Chromosome 15, band 15q21.1 — in an intron of FBN1.
What each result means
C/CNo copy of the version the research linked to Aortic aneurysm (PheCode 442.1). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Aortic aneurysm (PheCode 442.1). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Aortic aneurysm (PheCode 442.1). That is the strongest link of the three results. A link in a study is not a diagnosis.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs655015
What is rs655015?
rs655015 is a single position in the genome, in or near the FBN1 gene. Published research associates it with aortic aneurysm (phecode 442.1). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs655015 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs655015 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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