Standard
Glomerular filtration rate (creatinine)
ALMS1 · rs6546838
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
A/A
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Glomerular filtration rate (creatinine) compared to the general population.
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Glomerular filtration rate (creatinine).
G/G
Published research associates this genotype with typical/baseline likelihood of Glomerular filtration rate (creatinine) — no copies of the reported risk allele.
Source
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Pattaro C,
Teumer A,
Gorski M,
Chu AY,
Li M,
Mijatovic V,
Garnaas M,
Tin A,
Sorice R,
Li Y,
Taliun D,
Olden M
and 240 more — show all
Foster M,
Yang Q,
Chen MH,
Pers TH,
Johnson AD,
Ko YA,
Fuchsberger C,
Tayo B,
Nalls M,
Feitosa MF,
Isaacs A,
Dehghan A,
d'Adamo P,
Adeyemo A,
Dieffenbach AK,
Zonderman AB,
Nolte IM,
van der Most PJ,
Wright AF,
Shuldiner AR,
Morrison AC,
Hofman A,
Smith AV,
Dreisbach AW,
Franke A,
Uitterlinden AG,
Metspalu A,
Tonjes A,
Lupo A,
Robino A,
Johansson Å,
Demirkan A,
Kollerits B,
Freedman BI,
Ponte B,
Oostra BA,
Paulweber B,
Krämer BK,
Mitchell BD,
Buckley BM,
Peralta CA,
Hayward C,
Helmer C,
Rotimi CN,
Shaffer CM,
Müller C,
Sala C,
van Duijn CM,
Saint-Pierre A,
Ackermann D,
Shriner D,
Ruggiero D,
Toniolo D,
Lu Y,
Cusi D,
Czamara D,
Ellinghaus D,
Siscovick DS,
Ruderfer D,
Gieger C,
Grallert H,
Rochtchina E,
Atkinson EJ,
Holliday EG,
Boerwinkle E,
Salvi E,
Bottinger EP,
Murgia F,
Rivadeneira F,
Ernst F,
Kronenberg F,
Hu FB,
Navis GJ,
Curhan GC,
Ehret GB,
Homuth G,
Coassin S,
Thun GA,
Pistis G,
Gambaro G,
Malerba G,
Montgomery GW,
Eiriksdottir G,
Jacobs G,
Li G,
Wichmann HE,
Campbell H,
Schmidt H,
Wallaschofski H,
Völzke H,
Brenner H,
Kroemer HK,
Kramer H,
Lin H,
Leach IM,
Ford I,
Guessous I,
Rudan I,
Prokopenko I,
Borecki I,
Heid IM,
Kolcic I,
Persico I,
Jukema JW,
Wilson JF,
Felix JF,
Divers J,
Lambert JC,
Stafford JM,
Gaspoz JM,
Smith JA,
Faul JD,
Wang JJ,
Ding J,
Hirschhorn JN,
Attia J,
Whitfield JB,
Chalmers J,
Viikari J,
Coresh J,
Denny JC,
Karjalainen J,
Fernandes JK,
Endlich K,
Butterbach K,
Keene KL,
Lohman K,
Portas L,
Launer LJ,
Lyytikäinen LP,
Yengo L,
Franke L,
Ferrucci L,
Rose LM,
Kedenko L,
Rao M,
Struchalin M,
Kleber ME,
Cavalieri M,
Haun M,
Cornelis MC,
Ciullo M,
Pirastu M,
de Andrade M,
McEvoy MA,
Woodward M,
Adam M,
Cocca M,
Nauck M,
Imboden M,
Waldenberger M,
Pruijm M,
Metzger M,
Stumvoll M,
Evans MK,
Sale MM,
Kähönen M,
Boban M,
Bochud M,
Rheinberger M,
Verweij N,
Bouatia-Naji N,
Martin NG,
Hastie N,
Probst-Hensch N,
Soranzo N,
Devuyst O,
Raitakari O,
Gottesman O,
Franco OH,
Polasek O,
Gasparini P,
Munroe PB,
Ridker PM,
Mitchell P,
Muntner P,
Meisinger C,
Smit JH,
Kovacs P,
Wild PS,
Froguel P,
Rettig R,
Mägi R,
Biffar R,
Schmidt R,
Middelberg RP,
Carroll RJ,
Penninx BW,
Scott RJ,
Katz R,
Sedaghat S,
Wild SH,
Kardia SL,
Ulivi S,
Hwang SJ,
Enroth S,
Kloiber S,
Trompet S,
Stengel B,
Hancock SJ,
Turner ST,
Rosas SE,
Stracke S,
Harris TB,
Zeller T,
Zemunik T,
Lehtimäki T,
Illig T,
Aspelund T,
Nikopensius T,
Esko T,
Tanaka T,
Gyllensten U,
Völker U,
Emilsson V,
Vitart V,
Aalto V,
Gudnason V,
Chouraki V,
Chen WM,
Igl W,
März W,
Koenig W,
Lieb W,
Loos RJ,
Liu Y,
Snieder H,
Pramstaller PP,
Parsa A,
O'Connell JR,
Susztak K,
Hamet P,
Tremblay J,
de Boer IH,
Böger CA,
Goessling W,
Chasman DI,
Köttgen A,
Kao WH,
Fox CS
Nature communications · 2016 · PMID 26831199 · open access
Questions about rs6546838
What is rs6546838?
rs6546838 is a single position in the genome, in or near the ALMS1 gene. Published research associates it with glomerular filtration rate (creatinine). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs6546838 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6546838 come from?
GWAS Catalog, Nat Commun 2016, PMID:26831199. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants