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Who was studied 10,906 European ancestry cases, 366,221 European ancestry controls.
The effect
Each copy of the G allele carried 1.21 times the odds of Multiple myeloma (95% confidence interval 1.2-1.3); p = 7 × 10−22.
How common The G allele had a frequency of about 33% in the people studied.
Where it sits Chromosome 2, band 2p23.3 — between genes, 0.7 kb from KIF3C.
What each result means
C/CNo copy of the version the research linked to Multiple myeloma. This is the starting point the study compared everyone against.
C/GOne copy of the version the research linked to Multiple myeloma. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Multiple myeloma. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2024 · PMID 39103364 · open access
Questions about rs6546615
What is rs6546615?
rs6546615 is a single position in the genome, in or near the near KIF3C gene. Published research associates it with multiple myeloma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6546615 linked to?
On MyGeneLog this position is linked to Multiple Myeloma. The research behind each link, and its sources, are set out on that condition page.
Does having rs6546615 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6546615 come from?
GWAS Catalog, Nature communications 2024, PMID:39103364. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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