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Who was studied 737 Ashkenazi Jewish cases, 2,257 Ashkenazi Jewish controls; replicated in 971 Ashkenazi Jewish cases, 2,124 Ashkenazi Jewish controls.
The effect
Each copy of the C allele carried 1.16 times the odds of Crohn's disease (95% confidence interval 1.06-1.27); p = 7 × 10−9.
How common The C allele had a frequency of about 77% in the people studied.
Where it sits Chromosome 2, band 2p15 — in a regulatory region of TMEM17.
What each result means
C/CTwo copies of the version the research linked to Crohn's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Crohn's disease. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Crohn's disease. This is the starting point the study compared everyone against.
PLoS genetics · 2012 · PMID 22412388 · open access
Questions about rs6545946
What is rs6545946?
rs6545946 is a single position in the genome, in or near the TMEM17 gene. Published research associates it with crohn's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6545946 linked to?
On MyGeneLog this position is linked to Crohn's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs6545946 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6545946 come from?
GWAS Catalog, PLoS Genet 2012, PMID:22412388. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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