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Who was studied 86 European ancestry whole-genome sequenced cases, 4,280 European ancestry cases, 13,941 European ancestry whole-genome sequenced controls, 700,740 European ancestry controls.
The effect
Each copy of the T allele carried 1.15 times the odds of Nasal polyps (95% confidence interval 1.10-1.20); p = 7 × 10−10.
How common The T allele had a frequency of about 62% in the people studied.
Where it sits Chromosome 2, band 2q12.1 — in an intron of IL18R1.
What each result means
A/ANo copy of the version the research linked to Nasal polyps. This is the starting point the study compared everyone against.
A/TOne copy of the version the research linked to Nasal polyps. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Nasal polyps. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs6543124 is a single position in the genome, in or near the IL18R1 gene. Published research associates it with nasal polyps. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6543124 linked to?
On MyGeneLog this position is linked to Chronic Rhinosinusitis and the Bitter Taste Receptor. The research behind each link, and its sources, are set out on that condition page.
Does having rs6543124 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6543124 come from?
GWAS Catalog, Nat Genet 2019, PMID:30643255. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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