Standard
Lumbar spine bone mineral density
EN1 · rs6542457
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
C/C
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Lumbar spine bone mineral density compared to the general population.
C/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Lumbar spine bone mineral density.
G/G
Published research associates this genotype with typical/baseline likelihood of Lumbar spine bone mineral density — no copies of the reported risk allele.
Source
Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture
Zheng HF,
Forgetta V,
Hsu YH,
Estrada K,
Rosello-Diez A,
Leo PJ,
Dahia CL,
Park-Min KH,
Tobias JH,
Kooperberg C,
Kleinman A,
Styrkarsdottir U
and 146 more — show all
Liu CT,
Uggla C,
Evans DS,
Nielson CM,
Walter K,
Pettersson-Kymmer U,
McCarthy S,
Eriksson J,
Kwan T,
Jhamai M,
Trajanoska K,
Memari Y,
Min J,
Huang J,
Danecek P,
Wilmot B,
Li R,
Chou WC,
Mokry LE,
Moayyeri A,
Claussnitzer M,
Cheng CH,
Cheung W,
Medina-Gómez C,
Ge B,
Chen SH,
Choi K,
Oei L,
Fraser J,
Kraaij R,
Hibbs MA,
Gregson CL,
Paquette D,
Hofman A,
Wibom C,
Tranah GJ,
Marshall M,
Gardiner BB,
Cremin K,
Auer P,
Hsu L,
Ring S,
Tung JY,
Thorleifsson G,
Enneman AW,
van Schoor NM,
de Groot LC,
van der Velde N,
Melin B,
Kemp JP,
Christiansen C,
Sayers A,
Zhou Y,
Calderari S,
van Rooij J,
Carlson C,
Peters U,
Berlivet S,
Dostie J,
Uitterlinden AG,
Williams SR,
Farber C,
Grinberg D,
LaCroix AZ,
Haessler J,
Chasman DI,
Giulianini F,
Rose LM,
Ridker PM,
Eisman JA,
Nguyen TV,
Center JR,
Nogues X,
Nogues X,
Garcia-Giralt N,
Launer LL,
Gudnason V,
Mellström D,
Vandenput L,
Amin N,
van Duijn CM,
Karlsson MK,
Ljunggren Ö,
Svensson O,
Hallmans G,
Rousseau F,
Giroux S,
Bussière J,
Arp PP,
Koromani F,
Prince RL,
Lewis JR,
Langdahl BL,
Hermann AP,
Jensen JE,
Kaptoge S,
Khaw KT,
Reeve J,
Formosa MM,
Xuereb-Anastasi A,
Åkesson K,
McGuigan FE,
Garg G,
Olmos JM,
Zarrabeitia MT,
Riancho JA,
Ralston SH,
Alonso N,
Jiang X,
Goltzman D,
Pastinen T,
Grundberg E,
Gauguier D,
Orwoll ES,
Karasik D,
Davey-Smith G,
Smith AV,
Smith AV,
Siggeirsdottir K,
Harris TB,
Zillikens MC,
van Meurs JB,
Thorsteinsdottir U,
Maurano MT,
Timpson NJ,
Soranzo N,
Durbin R,
Wilson SG,
Ntzani EE,
Brown MA,
Stefansson K,
Hinds DA,
Spector T,
Cupples LA,
Ohlsson C,
Greenwood CM,
Jackson RD,
Rowe DW,
Loomis CA,
Evans DM,
Ackert-Bicknell CL,
Joyner AL,
Duncan EL,
Kiel DP,
Rivadeneira F,
Richards JB
Nature · 2015 · PMID 26367794
Questions about rs6542457
What is rs6542457?
rs6542457 is a single position in the genome, in or near the EN1 gene. Published research associates it with lumbar spine bone mineral density. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs6542457 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6542457 come from?
GWAS Catalog, Nature 2015, PMID:26367794. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants