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Non-HDL cholesterol levels

near RPS6KA3 · rs6527977

What the study found

Who was studied 749,391 European, East Asian, Hispanic, admixed African or South Asian ancestry men; replicated in 626 Arab ancestry men, 4,056 Asian ancestry men, 4,851 African ancestry men, 7,302 Hispanic men, 15,135 South Asian ancestry men, 17,511 African American men, 57,013 East Asian ancestry men, 65,334 European ancestry men.

The effect Each copy of the A allele shifted the measure 0.014 lower (95% confidence interval 0.0095-0.0185); p = 9 × 10−10.

How common The A allele had a frequency of about 16% in the people studied.

Where it sits Chromosome X, band Xp22.12 — between genes, 36.6 kb from RPS6KA3.

What each result means

A/A Two copies of the version the research linked to Non-HDL cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Non-HDL cholesterol levels. That is a smaller link than two copies.
C/C No copy of the version the research linked to Non-HDL cholesterol levels. This is the starting point the study compared everyone against.
Source

Questions about rs6527977

What is rs6527977?

rs6527977 is a single position in the genome, in or near the near RPS6KA3 gene. Published research associates it with non-hdl cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs6527977 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6527977 come from?

GWAS Catalog, Genome biology 2022, PMID:36575460. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Non-HDL cholesterol levels (rs6527977). MyGeneLog™. https://www.mygenelog.com/variants/rs6527977

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