Standard

Total body bone mineral density (age 45-60)

TSHZ3 · rs6510186

Where this position leads

Condition: Total Body Bone Mineral Density

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Total body bone mineral density (age 45-60) — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Total body bone mineral density (age 45-60).

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Total body bone mineral density (age 45-60) compared to the general population.

Source

Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects

Medina-Gomez C, Kemp JP, Trajanoska K, Luan J, Chesi A, Ahluwalia TS, Mook-Kanamori DO, Ham A, Hartwig FP, Evans DS, Joro R, Nedeljkovic I

and 77 more — show all

Zheng HF, Zhu K, Atalay M, Liu CT, Nethander M, Broer L, Porleifsson G, Mullin BH, Handelman SK, Nalls MA, Jessen LE, Heppe DHM, Richards JB, Wang C, Chawes B, Schraut KE, Amin N, Wareham N, Karasik D, Van der Velde N, Ikram MA, Zemel BS, Zhou Y, Carlsson CJ, Liu Y, McGuigan FE, Boer CG, Bønnelykke K, Ralston SH, Robbins JA, Walsh JP, Zillikens MC, Langenberg C, Li-Gao R, Williams FMK, Harris TB, Akesson K, Jackson RD, Sigurdsson G, den Heijer M, van der Eerden BCJ, van de Peppel J, Spector TD, Pennell C, Horta BL, Felix JF, Zhao JH, Wilson SG, de Mutsert R, Bisgaard H, Styrkársdóttir U, Jaddoe VW, Orwoll E, Lakka TA, Scott R, Grant SFA, Lorentzon M, van Duijn CM, Wilson JF, Stefansson K, Psaty BM, Kiel DP, Ohlsson C, Ntzani E, van Wijnen AJ, Forgetta V, Ghanbari M, Logan JG, Williams GR, Bassett JHD, Croucher PI, Evangelou E, Uitterlinden AG, Ackert-Bicknell CL, Tobias JH, Evans DM, Rivadeneira F

American journal of human genetics · 2018 · PMID 29304378

Questions about rs6510186

What is rs6510186?

rs6510186 is a single position in the genome, in or near the TSHZ3 gene. Published research associates it with total body bone mineral density (age 45-60). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6510186 linked to?

On MyGeneLog this position is linked to Total Body Bone Mineral Density. The research behind each link, and its sources, are set out on that condition page.

Does having rs6510186 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6510186 come from?

GWAS Catalog, Am J Hum Genet 2018, PMID:29304378. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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