Left ventricular mass indexed by body surface area
MAPT-AS1 · rs6503451
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 41,855 European ancestry individuals, 577 Asian or Pacific Islander individuals, 273 Black individuals, 198 Mixed ancestry individuals, 327 individuals.
The effect
Each copy of the T allele shifted the measure 0.52 lower (95% confidence interval 0.36-0.68); p = 1 × 10−10.
How common The T allele had a frequency of about 67% in the people studied.
Where it sits Chromosome 17, band 17q21.31 — in an intron of MAPT-AS1.
What each result means
C/CNo copy of the version the research linked to Left ventricular mass indexed by body surface area. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Left ventricular mass indexed by body surface area. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Left ventricular mass indexed by body surface area. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2023 · PMID 36944631 · open access
Questions about rs6503451
What is rs6503451?
rs6503451 is a single position in the genome, in or near the MAPT-AS1 gene. Published research associates it with left ventricular mass indexed by body surface area. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs6503451 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6503451 come from?
GWAS Catalog, Nature communications 2023, PMID:36944631. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
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Left ventricular mass indexed by body surface area (rs6503451). MyGeneLog™. https://www.mygenelog.com/variants/rs6503451