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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 33,748 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 8.5 z score higher; p = 2 × 10−17.
How common The T allele had a frequency of about 31% in the people studied.
Where it sits Chromosome 16, band 16q12.1 — between genes, 136 kb from HNRNPA1L3.
What each result means
C/CNo copy of the version the research linked to Vertex-wise cortical surface area. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Vertex-wise cortical surface area. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Vertex-wise cortical surface area. That is the strongest link of the three results. A link in a study is not a diagnosis.
Science advances · 2021 · PMID 34910505 · open access
Questions about rs6499196
What is rs6499196?
rs6499196 is a single position in the genome, in or near the near HNRNPA1L3 gene. Published research associates it with vertex-wise cortical surface area. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs6499196 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6499196 come from?
GWAS Catalog, Science advances 2021, PMID:34910505. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Vertex-wise cortical surface area (rs6499196). MyGeneLog™. https://www.mygenelog.com/variants/rs6499196