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Waist-to-hip ratio adjusted for body mass index

HSD11B2 · rs6499129

Where this position leads

Condition: Waist-to-Hip Ratio (Body Fat Distribution)

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Waist-to-hip ratio adjusted for body mass index compared to the general population.

A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Waist-to-hip ratio adjusted for body mass index.

C/C Published research associates this genotype with typical/baseline likelihood of Waist-to-hip ratio adjusted for body mass index — no copies of the reported risk allele.

Source

Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium

Ng MCY, Graff M, Lu Y, Justice AE, Mudgal P, Liu CT, Young K, Yanek LR, Feitosa MF, Wojczynski MK, Rand K, Brody JA

and 101 more — show all

Cade BE, Dimitrov L, Duan Q, Guo X, Lange LA, Nalls MA, Okut H, Tajuddin SM, Tayo BO, Vedantam S, Bradfield JP, Chen G, Chen WM, Chesi A, Irvin MR, Padhukasahasram B, Smith JA, Zheng W, Zheng W, Allison MA, Ambrosone CB, Bandera EV, Bartz TM, Berndt SI, Bernstein L, Blot WJ, Bottinger EP, Carpten J, Chanock SJ, Chen YI, Conti DV, Cooper RS, Fornage M, Freedman BI, Garcia M, Goodman PJ, Hsu YH, Hu J, Huff CD, Ingles SA, John EM, Kittles R, Klein E, Li J, McKnight B, Nayak U, Nemesure B, Ogunniyi A, Olshan A, Press MF, Rohde R, Rybicki BA, Salako B, Sanderson M, Shao Y, Siscovick DS, Stanford JL, Stevens VL, Stram A, Strom SS, Vaidya D, Witte JS, Yao J, Zhu X, Ziegler RG, Zonderman AB, Adeyemo A, Ambs S, Cushman M, Faul JD, Hakonarson H, Levin AM, Nathanson KL, Ware EB, Weir DR, Zhao W, Zhi D, Arnett DK, Grant SFA, Kardia SLR, Oloapde OI, Rao DC, Rotimi CN, Sale MM, Williams LK, Zemel BS, Becker DM, Borecki IB, Evans MK, Harris TB, Hirschhorn JN, Li Y, Patel SR, Psaty BM, Rotter JI, Wilson JG, Bowden DW, Cupples LA, Haiman CA, Loos RJF, North KE

Bone Mineral Density in Childhood Study (BMDCS) Group

PLoS genetics · 2017 · PMID 28430825 · open access

Questions about rs6499129

What is rs6499129?

rs6499129 is a single position in the genome, in or near the HSD11B2 gene. Published research associates it with waist-to-hip ratio adjusted for body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6499129 linked to?

On MyGeneLog this position is linked to Waist-to-Hip Ratio (Body Fat Distribution). The research behind each link, and its sources, are set out on that condition page.

Does having rs6499129 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6499129 come from?

GWAS Catalog, PLoS Genet 2017, PMID:28430825. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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