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Gamma glutamyltransferase levels (UKB data field 30730)

near AKAP13 · rs6497000

Where this position leads

Condition: Celiac Disease

rs6497000 Condition: Celiac Disease Celiac Disease Condition rs6497000 rs6497000 near AKAP13

What the study found

Who was studied 394,642 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0122 higher (95% confidence interval 0.0085-0.0158); p = 1 × 10−11.

How common The T allele had a frequency of about 42% in the people studied.

Where it sits Chromosome 15, band 15q25.3 — between genes, 52 kb from AKAP13.

What each result means

A/A No copy of the version the research linked to Gamma glutamyltransferase levels (UKB data field 30730). This is the starting point the study compared everyone against.
A/T One copy of the version the research linked to Gamma glutamyltransferase levels (UKB data field 30730). That is a smaller link than two copies.
T/T Two copies of the version the research linked to Gamma glutamyltransferase levels (UKB data field 30730). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs6497000

What is rs6497000?

rs6497000 is a single position in the genome, in or near the near AKAP13 gene. Published research associates it with gamma glutamyltransferase levels (ukb data field 30730). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6497000 linked to?

On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs6497000 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6497000 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Gamma glutamyltransferase levels (UKB data field 30730) (rs6497000). MyGeneLog™. https://www.mygenelog.com/variants/rs6497000

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