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Who was studied 62,543 European ancestry individuals (MTAG effective sample size boosted by osteoarthritis, rheumatoid arthritis and endometriosis samples).
The effect
Each copy of the A allele shifted the measure 0.042 lower (95% confidence interval 0.028-0.056); p = 2 × 10−8.
How common The A allele had a frequency of about 69% in the people studied.
Where it sits Chromosome 15, band 15q26.1 — between genes, 3.5 kb from GABARAPL3.
What each result means
A/ATwo copies of the version the research linked to Multiple sclerosis (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Multiple sclerosis (MTAG). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Multiple sclerosis (MTAG). This is the starting point the study compared everyone against.
Human reproduction (Oxford, England) · 2025 · PMID 40262193 · open access
Questions about rs6496664
What is rs6496664?
rs6496664 is a single position in the genome, in or near the near GABARAPL3 gene. Published research associates it with multiple sclerosis (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6496664 linked to?
On MyGeneLog this position is linked to Multiple Sclerosis. The research behind each link, and its sources, are set out on that condition page.
Does having rs6496664 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6496664 come from?
GWAS Catalog, Human reproduction (Oxford, England) 2025, PMID:40262193. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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