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Who was studied 2,370 Erasmus Rucphen Family (founder/genetic isolate) individuals, 29,325 European ancestry individuals; replicated in 391 Carlantino (founder/genetic isolate) individuals, 981 Friuli Venezia Giulia (founder/genetic isolate) individuals, 31,033 European ancestry individuals, 2,070 African American individuals.
The effect
Each copy of the G allele shifted the measure 1.16 lower (95% confidence interval 0.79-1.52); p = 5 × 10−10.
How common The G allele had a frequency of about 41% in the people studied.
Where it sits Chromosome 12, band 12q24.21 — in an intron of TBX3-AS1.
What each result means
A/ANo copy of the version the research linked to PR interval. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to PR interval. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to PR interval. That is the strongest link of the three results. A link in a study is not a diagnosis.
European journal of human genetics : EJHG · 2019 · PMID 30679814 · open access
Questions about rs6489973
What is rs6489973?
rs6489973 is a single position in the genome, in or near the TBX3 gene. Published research associates it with pr interval. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6489973 linked to?
On MyGeneLog this position is linked to Cardiac Conduction Intervals (PR Interval and QRS Duration). The research behind each link, and its sources, are set out on that condition page.
Does having rs6489973 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6489973 come from?
GWAS Catalog, European journal of human genetics : EJHG 2019, PMID:30679814. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 22Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others2Total2Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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