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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
1 / 4
Its strongest genetic-study result is p = 10−9, with 3 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 243,951 European and South Asian ancestry males.
The effect
Each copy of the A allele shifted the measure 0.0163 lower (95% confidence interval 0.011-0.022); p = 2 × 10−9.
How common The A allele had a frequency of about 41% in the people studied.
Where it sits Chromosome 12, band 12p12.1 — in an intron of SOX5.
What each result means
A/ATwo copies of the version the research linked to Testosterone levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Testosterone levels. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Testosterone levels. This is the starting point the study compared everyone against.
Nature genetics · 2025 · PMID 40229599 · open access
Questions about rs6487369
What is rs6487369?
rs6487369 is a single position in the genome, in or near the SOX5 gene. Published research associates it with testosterone levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs6487369 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6487369 come from?
GWAS Catalog, Nature genetics 2025, PMID:40229599. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license