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Who was studied 113,769 British ancestry cases, 208,811 British ancestry controls.
The effect
Each copy of the C allele shifted the measure 0.0069 higher (95% confidence interval 0.0045-0.0093); p = 3 × 10−8.
How common The C allele had a frequency of about 64% in the people studied.
Where it sits Chromosome 11, band 11q14.3 — in an intron of GRM5.
What each result means
C/CTwo copies of the version the research linked to Depression (broad). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Depression (broad). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Depression (broad). This is the starting point the study compared everyone against.
Nature communications · 2018 · PMID 29662059 · open access
Questions about rs6483414
What is rs6483414?
rs6483414 is a single position in the genome, in or near the GRM5 gene. Published research associates it with depression (broad). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6483414 linked to?
On MyGeneLog this position is linked to Depression (Self-Reported Symptoms). The research behind each link, and its sources, are set out on that condition page.
Does having rs6483414 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6483414 come from?
GWAS Catalog, Nat Commun 2018, PMID:29662059. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 261922327Reads by AI crawlersClaude0ChatGPT0Google · Gemini1Perplexity0Meta AI9Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others7Total26Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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