Sensitive

Chronic kidney disease

PHTF2 · rs6465825

Where this position leads

What the study found

Who was studied Up to 67,093 European ancestry individuals; replicated in Up to 22,982 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.01 lower (95% confidence interval 0.006-0.01); p = 2 × 10⁻⁹.

How common The C allele had a frequency of about 39% in the people studied.

Where it sits Chromosome 7, band 7q11.23 — between genes, 4.1 kb from RSBN1L.

What each result means

C/C Two copies of the version the research linked to Chronic kidney disease. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Chronic kidney disease. That is a smaller link than two copies.

T/T No copy of the version the research linked to Chronic kidney disease. This is the starting point the study compared everyone against.

Source

New loci associated with kidney function and chronic kidney disease

Köttgen A, Pattaro C, Böger CA, Fuchsberger C, Olden M, Glazer NL, Parsa A, Gao X, Yang Q, Smith AV, O'Connell JR, Li M

and 120 more — show all

Schmidt H, Tanaka T, Isaacs A, Ketkar S, Hwang SJ, Johnson AD, Dehghan A, Teumer A, Paré G, Atkinson EJ, Zeller T, Lohman K, Cornelis MC, Probst-Hensch NM, Kronenberg F, Tönjes A, Hayward C, Aspelund T, Eiriksdottir G, Launer LJ, Harris TB, Rampersaud E, Mitchell BD, Arking DE, Boerwinkle E, Struchalin M, Cavalieri M, Singleton A, Giallauria F, Metter J, de Boer IH, Haritunians T, Lumley T, Siscovick D, Psaty BM, Zillikens MC, Oostra BA, Feitosa M, Province M, de Andrade M, Turner ST, Schillert A, Ziegler A, Wild PS, Schnabel RB, Wilde S, Munzel TF, Leak TS, Illig T, Klopp N, Meisinger C, Wichmann HE, Koenig W, Zgaga L, Zemunik T, Kolcic I, Minelli C, Hu FB, Johansson A, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Schreiber S, Aulchenko YS, Felix JF, Rivadeneira F, Uitterlinden AG, Hofman A, Imboden M, Nitsch D, Brandstätter A, Kollerits B, Kedenko L, Mägi R, Stumvoll M, Kovacs P, Boban M, Campbell S, Endlich K, Völzke H, Kroemer HK, Nauck M, Völker U, Polasek O, Vitart V, Badola S, Parker AN, Ridker PM, Kardia SL, Blankenberg S, Liu Y, Curhan GC, Franke A, Rochat T, Paulweber B, Prokopenko I, Wang W, Gudnason V, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, Shlipak MG, van Duijn CM, Borecki I, Krämer BK, Rudan I, Gyllensten U, Wilson JF, Witteman JC, Pramstaller PP, Rettig R, Hastie N, Chasman DI, Kao WH, Heid IM, Fox CS

Nature genetics · 2010 · PMID 20383146

Questions about rs6465825

What is rs6465825?

rs6465825 is a single position in the genome, in or near the PHTF2 gene. Published research associates it with chronic kidney disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6465825 linked to?

On MyGeneLog this position is linked to Kidney Function. The research behind each link, and its sources, are set out on that condition page.

Does having rs6465825 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6465825 come from?

GWAS Catalog, Nat Genet 2010, PMID:20383146. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Chronic kidney disease (rs6465825). MyGeneLog™. https://www.mygenelog.com/variants/rs6465825

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