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Who was studied 3,037,499 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.00959 lower (95% confidence interval 0.007-0.0122); p = 3 × 10−13.
How common The A allele had a frequency of about 80% in the people studied.
Where it sits Chromosome 11, band 11q13.1 — in an intron of MACROD1.
What each result means
A/ATwo copies of the version the research linked to Educational attainment. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Educational attainment. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Educational attainment. This is the starting point the study compared everyone against.
Nature genetics · 2022 · PMID 35361970 · open access
Questions about rs646384
What is rs646384?
rs646384 is a single position in the genome, in or near the MACROD1 gene. Published research associates it with educational attainment. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs646384 linked to?
On MyGeneLog this position is linked to Educational Attainment. The research behind each link, and its sources, are set out on that condition page.
Does having rs646384 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs646384 come from?
GWAS Catalog, Nature genetics 2022, PMID:35361970. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 6123Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others3Total6Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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