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Who was studied 29,266 European ancestry lung cancer cases, 48,843 European ancestry individuals with family history of lung cancer, 251,837 European ancestry controls.
The effect
Each copy of the G allele carried 1.08 times the odds of Lung cancer or family history of lung cancer (95% confidence interval 1.058-1.099); p = 3 × 10−13.
How common The G allele had a frequency of about 40% in the people studied.
Where it sits Chromosome 6, band 6p21.33 — between genes, 8.1 kb from HCG22.
What each result means
A/ANo copy of the version the research linked to Lung cancer or family history of lung cancer. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Lung cancer or family history of lung cancer. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Lung cancer or family history of lung cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
Journal of the National Cancer Institute · 2022 · PMID 35511172 · open access
Questions about rs6457312
What is rs6457312?
rs6457312 is a single position in the genome, in or near the near HCG22 gene. Published research associates it with lung cancer or family history of lung cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6457312 linked to?
On MyGeneLog this position is linked to Lung Cancer. The research behind each link, and its sources, are set out on that condition page.
Does having rs6457312 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6457312 come from?
GWAS Catalog, Journal of the National Cancer Institute 2022, PMID:35511172. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 5122Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total5Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Lung cancer or family history of lung cancer (rs6457312). MyGeneLog™. https://www.mygenelog.com/variants/rs6457312