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Psoriasis

POLR1HASP · rs6457109

Where this position leads

Condition: Psoriasis

rs6457109 Condition: Psoriasis Psoriasis Condition rs6457109 rs6457109 POLR1HASP

What the study found

Who was studied 20,105 European ancestry cases, 842,975 European ancestry controls.

The effect Each copy of the T allele shifted the measure 0.4 lower (95% confidence interval 0.35-0.45); p = 8 × 10−58.

How common The T allele had a frequency of about 93% in the people studied.

Where it sits Chromosome 6, band 6p22.1 — in an intron of POLR1HASP.

What each result means

C/C No copy of the version the research linked to Psoriasis. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Psoriasis. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Psoriasis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Novel genetic insight for psoriasis: integrative genome-wide analyses in 863 080 individuals and proteome-wide Mendelian randomization
Liu S, Li L, Liang Y, Tan Y, Wang X, Feng Y, Chen N, Lei X
Briefings in bioinformatics · 2024 · PMID 39883516 · open access

Questions about rs6457109

What is rs6457109?

rs6457109 is a single position in the genome, in or near the POLR1HASP gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6457109 linked to?

On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.

Does having rs6457109 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6457109 come from?

GWAS Catalog, Briefings in bioinformatics 2024, PMID:39883516. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Psoriasis (rs6457109). MyGeneLog™. https://www.mygenelog.com/variants/rs6457109

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