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Who was studied at least 33,640 European ancestry cases, at least 43,456 European ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.069 higher (95% confidence interval 0.048-0.09); p = 2 × 10−10.
How common The A allele had a frequency of about 47% in the people studied.
Where it sits Chromosome 5, band 5q12.1 — in an intron of ZSWIM6.
What each result means
A/ATwo copies of the version the research linked to Schizophrenia (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Schizophrenia (MTAG). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Schizophrenia (MTAG). This is the starting point the study compared everyone against.
Translational psychiatry · 2021 · PMID 33479212 · open access
Questions about rs6449528
What is rs6449528?
rs6449528 is a single position in the genome, in or near the ZSWIM6 gene. Published research associates it with schizophrenia (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6449528 linked to?
On MyGeneLog this position is linked to Schizophrenia. The research behind each link, and its sources, are set out on that condition page.
Does having rs6449528 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6449528 come from?
GWAS Catalog, Translational psychiatry 2021, PMID:33479212. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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