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Body mass index

KCTD8 · rs6447335

Where this position leads

Condition: Childhood Body Mass Index

rs6447335 Condition: Childhood Body Mass Index Childhood Body Mass Index Condition rs6447335 rs6447335 KCTD8

What the study found

Who was studied 441,761 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0143 lower (95% confidence interval 0.0099-0.0187); p = 3 × 10−10.

Where it sits Chromosome 4, band 4p13 — in an intron of KCTD8.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Body mass index — no copies of the reported risk allele.
C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Body mass index.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Body mass index compared to the general population.
Source
Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood
Hawkes G, Beaumont RN, Tyrrell J, Power GM, Wood A, Laakso M, Fernandes Silva L, Boehnke M, Yin X, Richardson TG, Smith GD, Frayling TM
Diabetologia · 2023 · PMID 37280435 · open access

Questions about rs6447335

What is rs6447335?

rs6447335 is a single position in the genome, in or near the KCTD8 gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6447335 linked to?

On MyGeneLog this position is linked to Childhood Body Mass Index. The research behind each link, and its sources, are set out on that condition page.

Does having rs6447335 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6447335 come from?

GWAS Catalog, Diabetologia 2023, PMID:37280435. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Body mass index (rs6447335). MyGeneLog™. https://www.mygenelog.com/variants/rs6447335

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