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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 46,685 European ancestry individuals; replicated in 4,765 non-European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 1.22 higher (95% confidence interval 0.89-1.54); p = 2 × 10−13.
How common The A allele had a frequency of about 45% in the people studied.
Where it sits Chromosome 3, band 3q26.31 — in an intron of TNIK.
What each result means
A/ATwo copies of the version the research linked to Corpus callosum splenium area. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Corpus callosum splenium area. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Corpus callosum splenium area. This is the starting point the study compared everyone against.
Nature communications · 2025 · PMID 41188267 · open access
Questions about rs6444974
What is rs6444974?
rs6444974 is a single position in the genome, in or near the TNIK gene. Published research associates it with corpus callosum splenium area. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs6444974 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6444974 come from?
GWAS Catalog, Nature communications 2025, PMID:41188267. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Corpus callosum splenium area (rs6444974). MyGeneLog™. https://www.mygenelog.com/variants/rs6444974