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Standard

Low density lipoprotein cholesterol levels

TRIM59-IFT80 · rs6441313

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−14, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 1,320,016 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0126 lower (95% confidence interval 0.0098-0.0153); p = 2 × 10−14.

How common The G allele had a frequency of about 54% in the people studied.

Where it sits Chromosome 3, band 3q25.33 — in an intron of TRIM59-IFT80.

How common each version is

AG
Korean KRGDB
A 78.3% · G 21.7%
Korean Korea4K
A 78.7% · G 21.3%
Korean Korea1K
A 78.4% · G 21.6%
Japanese ToMMo
A 74.5% · G 25.5%
Vietnamese
A 72.7% · G 27.3%
World gnomAD
A 47.6% · G 52.4%
World 1000 Genomes
A 55.9% · G 44.1%
World TOPMed
A 48.4% · G 51.6%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A No copy of the version the research linked to Low density lipoprotein cholesterol levels. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Low density lipoprotein cholesterol levels. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Low density lipoprotein cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Quoting this page

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Low density lipoprotein cholesterol levels (rs6441313). MyGeneLog™. https://www.mygenelog.com/variants/rs6441313

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