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Smoking initiation

ZBTB20 · rs6438208

What the study found

Who was studied 842,717 European ancestry individuals.

The effect Each copy of the A allele carried 0.97 times the odds of Smoking initiation; p = 3 × 10−10.

Where it sits Chromosome 3, band 3q13.31 — in an intron of ZBTB20-AS5.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Smoking initiation compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Smoking initiation.
G/G Published research associates this genotype with typical/baseline likelihood of Smoking initiation — no copies of the reported risk allele.
Source

Questions about rs6438208

What is rs6438208?

rs6438208 is a single position in the genome, in or near the ZBTB20 gene. Published research associates it with smoking initiation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs6438208 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6438208 come from?

GWAS Catalog, Nature communications 2020, PMID:33082346. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Smoking initiation (rs6438208). MyGeneLog™. https://www.mygenelog.com/variants/rs6438208

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