Standard

Eosinophil count

ATM · rs637064

Where this position leads

Condition: Blood Cell Counts

Drug: Metformin

rs637064 Condition: Blood Cell Counts Blood Cell Counts Condition Drug: Metformin Metformin Drug rs637064 rs637064 ATM

What the study found

Who was studied 474,237 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0243 SD unit higher (95% confidence interval 0.02-0.028); p = 5 × 10−34.

How common The T allele had a frequency of about 56% in the people studied.

Where it sits Chromosome 11, band 11q22.3 — in an intron of ATM.

What ClinVar records

Classification Benign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2018-07-09. ClinVar record 1245917 NM_000051.4(ATM):c.2839-882C>T

What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C No copy of the version the research linked to Eosinophil count. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Eosinophil count. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Eosinophil count. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs637064

What is rs637064?

rs637064 is a single position in the genome, in or near the ATM gene. Published research associates it with eosinophil count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs637064 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does rs637064 affect how medicines work?

ATM carries pharmacogenomic findings for Metformin. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs637064 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs637064 come from?

GWAS Catalog, Cell 2020, PMID:32888493. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Eosinophil count (rs637064). MyGeneLog™. https://www.mygenelog.com/variants/rs637064

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