Who was studied 524,923 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0295 SD unit lower (95% confidence interval 0.022-0.037); p = 2 × 10−13.
How common The T allele had a frequency of about 6% in the people studied.
Where it sits Chromosome 1, band 1q23.1 — a missense change in NTRK1.
What ClinVar records
ClassificationBenign/Likely benign for Familial medullary thyroid carcinoma, Hereditary insensitivity to pain with anhidrosis; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 20 submitters), last evaluated 2026-02-04.
ClinVar record 12308NM_002529.4(NTRK1):c.1838G>T (p.Gly613Val)
What this is ClinVar's aggregate record for this position (as of its 2026-09-24 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
G/GPublished research associates this genotype with typical/baseline likelihood of Lymphocyte count — no copies of the reported risk allele.
G/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Lymphocyte count.
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Lymphocyte count compared to the general population.
rs6339 is a single position in the genome, in or near the NTRK1 gene. Published research associates it with lymphocyte count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6339 linked to?
On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.
Does having rs6339 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6339 come from?
GWAS Catalog, Cell 2020, PMID:32888493. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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