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Thyroid-stimulating hormone levels

MUS81 · rs630755

What the study found

Who was studied 153,950 Korean ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0309 higher (95% confidence interval 0.022-0.039); p = 2 × 10−12.

How common The A allele had a frequency of about 30% in the people studied.

Where it sits Chromosome 11, band 11q13.1 — in an intron of MUS81.

What each result means

A/A Two copies of the version the research linked to Thyroid-stimulating hormone levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Thyroid-stimulating hormone levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to Thyroid-stimulating hormone levels. This is the starting point the study compared everyone against.
Source

Questions about rs630755

What is rs630755?

rs630755 is a single position in the genome, in or near the MUS81 gene. Published research associates it with thyroid-stimulating hormone levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs630755 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs630755 come from?

GWAS Catalog, Nature communications 2025, PMID:40436827. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Thyroid-stimulating hormone levels (rs630755). MyGeneLog™. https://www.mygenelog.com/variants/rs630755

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