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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 259,608 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0393 lower (95% confidence interval 0.032-0.047); p = 3 × 10−24.
How common The T allele had a frequency of about 25% in the people studied.
Where it sits Chromosome 6, band 6p24.3 — in an intron of RREB1.
What each result means
C/CNo copy of the version the research linked to monocyte (absolute count, mean, inv-norm transformed). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to monocyte (absolute count, mean, inv-norm transformed). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to monocyte (absolute count, mean, inv-norm transformed). That is the strongest link of the three results. A link in a study is not a diagnosis.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs630258
What is rs630258?
rs630258 is a single position in the genome, in or near the RREB1 gene. Published research associates it with monocyte (absolute count, mean, inv-norm transformed). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs630258 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs630258 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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