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Chronic obstructive pulmonary disease

DENND2D · rs629619

Where this position leads

Condition: Chronic Obstructive Pulmonary Disease (COPD)

rs629619 Condition: Chronic Obstructive Pulmonary Disease (COPD) Chronic Obstructive Pulmonary Disea… Condition rs629619 rs629619 DENND2D

What the study found

Who was studied 35,735 cases, 222,076 controls.

The effect Each copy of the T allele carried 1.08 times the odds of Chronic obstructive pulmonary disease (95% confidence interval 1.06-1.11); p = 3 × 10−10.

How common The T allele had a frequency of about 20% in the people studied.

Where it sits Chromosome 1, band 1p13.3 — in an intron of DENND2D.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Chronic obstructive pulmonary disease — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Chronic obstructive pulmonary disease.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Chronic obstructive pulmonary disease compared to the general population.
Source
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations
Sakornsakolpat P, Prokopenko D, Lamontagne M, Reeve NF, Guyatt AL, Jackson VE, Shrine N, Qiao D, Bartz TM, Kim DK, Lee MK, Latourelle JC
and 42 more — show all
Li X, Morrow JD, Obeidat M, Wyss AB, Bakke P, Barr RG, Beaty TH, Belinsky SA, Brusselle GG, Crapo JD, de Jong K, DeMeo DL, Fingerlin TE, Gharib SA, Gulsvik A, Hall IP, Hokanson JE, Kim WJ, Lomas DA, London SJ, Meyers DA, O'Connor GT, Rennard SI, Schwartz DA, Sliwinski P, Sparrow D, Strachan DP, Tal-Singer R, Tesfaigzi Y, Vestbo J, Vonk JM, Yim JJ, Zhou X, Bossé Y, Manichaikul A, Lahousse L, Silverman EK, Boezen HM, Wain LV, Tobin MD, Hobbs BD, Cho MH
SpiroMeta Consortium · International COPD Genetics Consortium
Nature genetics · 2019 · PMID 30804561 · open access

Questions about rs629619

What is rs629619?

rs629619 is a single position in the genome, in or near the DENND2D gene. Published research associates it with chronic obstructive pulmonary disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs629619 linked to?

On MyGeneLog this position is linked to Chronic Obstructive Pulmonary Disease (COPD). The research behind each link, and its sources, are set out on that condition page.

Does having rs629619 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs629619 come from?

GWAS Catalog, Nature genetics 2019, PMID:30804561. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Chronic obstructive pulmonary disease (rs629619). MyGeneLog™. https://www.mygenelog.com/variants/rs629619

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