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Brain age gap derived from combined gray and white matter

DHRSX · rs62595479

What the study found

Who was studied 32,634 European ancestry individuals; replicated in 22,256 European ancestry individuals, 337 African ancestry individuals, 94 Hispanic or Latin American individuals, 638 Central Asian or South Asian ancestry individuals, 291 East Asian ancestry individuals, 98 Middle Eastern ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.208 years higher (95% confidence interval 0.15-0.27); p = 2 × 10−11.

How common The T allele had a frequency of about 23% in the people studied.

Where it sits Chromosome Y, band Yp11.2 — in an intron of DHRSX.

What each result means

C/C No copy of the version the research linked to Brain age gap derived from combined gray and white matter. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Brain age gap derived from combined gray and white matter. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Brain age gap derived from combined gray and white matter. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs62595479

What is rs62595479?

rs62595479 is a single position in the genome, in or near the DHRSX gene. Published research associates it with brain age gap derived from combined gray and white matter. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs62595479 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs62595479 come from?

GWAS Catalog, Nature aging 2025, PMID:41044200. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Brain age gap derived from combined gray and white matter (rs62595479). MyGeneLog™. https://www.mygenelog.com/variants/rs62595479

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