Phospholipids to Total Lipids in Large LDL percentage
SIGLEC1 · rs625372
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Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.
The effect
Each copy of the C allele shifted the measure 0.02 % higher (95% confidence interval 0.02-0.02); p = 3 × 10−13.
Where it sits Chromosome 20, band 20p13 — a missense change in SIGLEC1.
What each result means
C/CTwo copies of the version the research linked to Phospholipids to Total Lipids in Large LDL percentage. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Phospholipids to Total Lipids in Large LDL percentage. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Phospholipids to Total Lipids in Large LDL percentage. This is the starting point the study compared everyone against.
Nature genetics · 2025 · PMID 41044249 · open access
Questions about rs625372
What is rs625372?
rs625372 is a single position in the genome, in or near the SIGLEC1 gene. Published research associates it with phospholipids to total lipids in large ldl percentage. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs625372 linked to?
On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.
Does having rs625372 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs625372 come from?
GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 5122Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total5Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Phospholipids to Total Lipids in Large LDL percentage (rs625372). MyGeneLog™. https://www.mygenelog.com/variants/rs625372