Standard

Glaucoma (primary open-angle)

FBXO32 · rs62521288

Where this position leads

Condition: Glaucoma

rs62521288 Condition: Glaucoma Glaucoma Condition rs62521288 rs62521288 FBXO32

What the study found

Who was studied 23,963 European ancestry cases, 306,942 European ancestry controls, 6,935 East Asian ancestry cases, 39,588 East Asian ancestry controls, 3,281 Sub-Saharan African ancestry cases, 2,791 Sub-Saharan African ancestry controls; replicated in 43,254 European ancestry cases, 1,471,118 European ancestry controls.

The effect Each copy of the A allele shifted the measure 0.139 lower; p = 4 × 10−22.

Where it sits Chromosome 8, band 8q24.13 — between genes, 0.8 kb from FBXO32.

What each result means

A/A Two copies of the version the research linked to Glaucoma (primary open-angle). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/T One copy of the version the research linked to Glaucoma (primary open-angle). That is a smaller link than two copies.
T/T No copy of the version the research linked to Glaucoma (primary open-angle). This is the starting point the study compared everyone against.
Source

Questions about rs62521288

What is rs62521288?

rs62521288 is a single position in the genome, in or near the FBXO32 gene. Published research associates it with glaucoma (primary open-angle). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs62521288 linked to?

On MyGeneLog this position is linked to Glaucoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs62521288 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs62521288 come from?

GWAS Catalog, Nature communications 2021, PMID:33627673. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Glaucoma (primary open-angle) (rs62521288). MyGeneLog™. https://www.mygenelog.com/variants/rs62521288

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