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Standard

Low density lipoprotein cholesterol levels

LY96 · rs62509311

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−17, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 1,320,016 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0153 lower (95% confidence interval 0.012-0.018); p = 3 × 10−17.

How common The T allele had a frequency of about 28% in the people studied.

Where it sits Chromosome 8, band 8q21.11 — in an intron of LY96.

How common each version is

AT
Korean KRGDB
A 85.0% · T 14.9%
Korean Korea4K
A 83.5% · T 16.5%
Korean Korea1K
A 83.0% · T 17.0%
Japanese ToMMo
A 86.4% · T 13.6%
Vietnamese
A 85.5% · T 14.5%
World gnomAD
A 80.8% · T 19.2%
World 1000 Genomes
A 83.5% · T 16.4%
World TOPMed
A 81.8% · T 18.2%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A No copy of the version the research linked to Low density lipoprotein cholesterol levels. This is the starting point the study compared everyone against.
A/T One copy of the version the research linked to Low density lipoprotein cholesterol levels. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Low density lipoprotein cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Quoting this page

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Low density lipoprotein cholesterol levels (rs62509311). MyGeneLog™. https://www.mygenelog.com/variants/rs62509311

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