PLEKHG1 · rs62434123
Where this position leads
Condition: Medication Use as a Genetic Trait
What the study found
Who was studied 31,904 European ancestry cases, 172,474 European ancestry controls.
The effect Each copy of the T allele shifted the measure 0.0905 lower (95% confidence interval 0.06-0.121); p = 7 × 10−9.
How common The T allele had a frequency of about 7% in the people studied.
Where it sits Chromosome 6, band 6q25.1 — in an intron of PLEKHG1.
rs62434123 is a single position in the genome, in or near the PLEKHG1 gene. Published research associates it with medication use (calcium channel blockers). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Medication Use as a Genetic Trait. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nat Commun 2019, PMID:31015401. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Medication use (calcium channel blockers) (rs62434123). MyGeneLog™. https://www.mygenelog.com/variants/rs62434123