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Systolic blood pressure

PLEKHG1 · rs62434120

Where this position leads

Condition: Blood Pressure

rs62434120 Condition: Blood Pressure Blood Pressure Condition rs62434120 rs62434120 PLEKHG1

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Systolic blood pressure — no copies of the reported risk allele.
A/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Systolic blood pressure.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Systolic blood pressure compared to the general population.
Source
Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations
Liang J, Le TH, Edwards DRV, Tayo BO, Gaulton KJ, Smith JA, Lu Y, Jensen RA, Chen G, Yanek LR, Schwander K, Tajuddin SM
and 69 more — show all
Sofer T, Kim W, Kayima J, McKenzie CA, Fox E, Nalls MA, Young JH, Sun YV, Lane JM, Cechova S, Zhou J, Tang H, Fornage M, Musani SK, Wang H, Lee J, Adeyemo A, Dreisbach AW, Forrester T, Chu PL, Cappola A, Evans MK, Morrison AC, Martin LW, Wiggins KL, Hui Q, Zhao W, Jackson RD, Ware EB, Faul JD, Reiner AP, Bray M, Denny JC, Mosley TH, Palmas W, Guo X, Papanicolaou GJ, Penman AD, Polak JF, Rice K, Rice K, Taylor KD, Boerwinkle E, Bottinger EP, Liu K, Risch N, Hunt SC, Kooperberg C, Zonderman AB, Laurie CC, Becker DM, Cai J, Loos RJF, Psaty BM, Weir DR, Kardia SLR, Arnett DK, Won S, Edwards TL, Redline S, Cooper RS, Rao DC, Rotter JI, Rotimi C, Levy D, Chakravarti A, Zhu X, Franceschini N, Franceschini N
PLoS genetics · 2017 · PMID 28498854 · open access

Questions about rs62434120

What is rs62434120?

rs62434120 is a single position in the genome, in or near the PLEKHG1 gene. Published research associates it with systolic blood pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs62434120 linked to?

On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.

Does having rs62434120 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs62434120 come from?

GWAS Catalog, PLoS Genet 2017, PMID:28498854. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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