Sensitive

Rheumatoid arthritis

ATG5 · rs62422878

Where this position leads

Condition: Rheumatoid Arthritis

rs62422878 Condition: Rheumatoid Arthritis Rheumatoid Arthritis Condition rs62422878 rs62422878 ATG5

What the study found

Who was studied 14,361 European ancestry cases, 43,923 European ancestry controls, 8,267 East Asian ancestry cases, 244,741 East Asian ancestry controls.

The effect Each copy of the T allele carried 1.11 times the odds of Rheumatoid arthritis (95% confidence interval 1.07-1.15); p = 4 × 10−9.

Where it sits Chromosome 6, band 6q21 — in an intron of ATG5.

What each result means

C/C No copy of the version the research linked to Rheumatoid arthritis. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Rheumatoid arthritis. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Rheumatoid arthritis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs62422878

What is rs62422878?

rs62422878 is a single position in the genome, in or near the ATG5 gene. Published research associates it with rheumatoid arthritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs62422878 linked to?

On MyGeneLog this position is linked to Rheumatoid Arthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs62422878 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs62422878 come from?

GWAS Catalog, Annals of the rheumatic diseases 2021, PMID:33310728. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Rheumatoid arthritis (rs62422878). MyGeneLog™. https://www.mygenelog.com/variants/rs62422878

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