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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
1 / 4
Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 344,052 European ancestry individuals, 148,767 East Asian ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.0279 lower (95% confidence interval 0.019-0.037); p = 4 × 10−9.
Where it sits Chromosome 4, band 4p15.31 — between genes, 149.2 kb from LCORL.
What each result means
A/ANo copy of the version the research linked to Blood urea nitrogen levels. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Blood urea nitrogen levels. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Blood urea nitrogen levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs62411644 is a single position in the genome, in or near the near LCORL gene. Published research associates it with blood urea nitrogen levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs62411644 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs62411644 come from?
GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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