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Who was studied 9,626 European ancestry cases, 685,602 European ancestry controls.
The effect
Each copy of the G allele carried 1.15 times the odds of Chronic rhinosinusitis with nasal polyposis (95% confidence interval 1.115-1.191); p = 1 × 10−17.
How common The G allele had a frequency of about 25% in the people studied.
Where it sits Chromosome 6, band 6q15 — in an intron of BACH2.
What each result means
A/APublished research associates this genotype with typical/baseline likelihood of Chronic rhinosinusitis with nasal polyposis — no copies of the reported risk allele.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Chronic rhinosinusitis with nasal polyposis.
G/GPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Chronic rhinosinusitis with nasal polyposis compared to the general population.
Nature communications · 2025 · PMID 41213931 · open access
Questions about rs62408224
What is rs62408224?
rs62408224 is a single position in the genome, in or near the BACH2 gene. Published research associates it with chronic rhinosinusitis with nasal polyposis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs62408224 linked to?
On MyGeneLog this position is linked to Chronic Rhinosinusitis with Nasal Polyps. The research behind each link, and its sources, are set out on that condition page.
Does having rs62408224 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs62408224 come from?
GWAS Catalog, Nature communications 2025, PMID:41213931. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
5 2411212314Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity1Meta AI2Microsoft · Copilot1Amazon2Apple3Others14Total24Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Chronic rhinosinusitis with nasal polyposis (rs62408224). MyGeneLog™. https://www.mygenelog.com/variants/rs62408224