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Who was studied 27,993 European ancestry individuals, 6,949 Black individuals, 6,530 Hispanic individuals, 55 individuals.
The effect
Each copy of the A allele shifted the measure 0.042 lower (95% confidence interval -0.12852-0.21252); p = 4 × 10−12.
How common The A allele had a frequency of about 2% in the people studied.
Where it sits Chromosome 5, band 5q33.3 — in an intron of ADRA1B.
What each result means
A/ATwo copies of the version the research linked to Alzheimer's disease (age of onset). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Alzheimer's disease (age of onset). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Alzheimer's disease (age of onset). This is the starting point the study compared everyone against.
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025 · PMID 40883957 · open access
Questions about rs62377696
What is rs62377696?
rs62377696 is a single position in the genome, in or near the ADRA1B gene. Published research associates it with alzheimer's disease (age of onset). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs62377696 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs62377696 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs62377696 come from?
GWAS Catalog, Alzheimer's & dementia : the journal of the Alzheimer's Association 2025, PMID:40883957. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 1512318Reads by AI crawlersClaude0ChatGPT0Google · Gemini1Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others8Total15Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Alzheimer's disease (age of onset) (rs62377696). MyGeneLog™. https://www.mygenelog.com/variants/rs62377696