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Left ventricular global radial strain

CWC27 · rs62371001

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 19,260 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.592 higher (95% confidence interval 0.39-0.79); p = 9 × 10−9.

How common The G allele had a frequency of about 17% in the people studied.

Where it sits Chromosome 5, band 5q12.3 — inside CWC27.

What each result means

A/A No copy of the version the research linked to Left ventricular global radial strain. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Left ventricular global radial strain. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Left ventricular global radial strain. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect
Tadros R, Francis C, Xu X, Vermeer AMC, Harper AR, Huurman R, Kelu Bisabu K, Walsh R, Hoorntje ET, Te Rijdt WP, Buchan RJ, van Velzen HG
and 58 more — show all
van Slegtenhorst MA, Vermeulen JM, Offerhaus JA, Bai W, de Marvao A, Lahrouchi N, Beekman L, Karper JC, Veldink JH, Kayvanpour E, Pantazis A, Baksi AJ, Whiffin N, Mazzarotto F, Sloane G, Suzuki H, Schneider-Luftman D, Elliott P, Richard P, Ader F, Villard E, Lichtner P, Meitinger T, Tanck MWT, van Tintelen JP, Thain A, McCarty D, Hegele RA, Roberts JD, Amyot J, Dubé MP, Cadrin-Tourigny J, Giraldeau G, L'Allier PL, Garceau P, Tardif JC, Boekholdt SM, Lumbers RT, Asselbergs FW, Barton PJR, Cook SA, Prasad SK, O'Regan DP, van der Velden J, Verweij KJH, Talajic M, Lettre G, Pinto YM, Meder B, Charron P, de Boer RA, Christiaans I, Michels M, Wilde AAM, Watkins H, Matthews PM, Ware JS, Bezzina CR
Nature genetics · 2021 · PMID 33495596 · open access

Questions about rs62371001

What is rs62371001?

rs62371001 is a single position in the genome, in or near the CWC27 gene. Published research associates it with left ventricular global radial strain. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs62371001 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs62371001 come from?

GWAS Catalog, Nature genetics 2021, PMID:33495596. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Left ventricular global radial strain (rs62371001). MyGeneLog™. https://www.mygenelog.com/variants/rs62371001

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