Standard

LDL cholesterol

DOK7 · rs62275880

Where this position leads

Conditions: Colon Polyp, Cholesterol (LDL, HDL and Total)

rs62275880 Condition: Colon Polyp Colon Polyp Condition Condition: Cholesterol (LDL, HDL and Total) Cholesterol (LDL, HDL and Total) Condition rs62275880 rs62275880 DOK7

What the study found

Who was studied 343,621 European ancestry individuals, 72,866 East Asian ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.02 higher (95% confidence interval 0.015-0.025); p = 1 × 10−13.

Where it sits Chromosome 4, band 4p16.3 — in an intron of DOK7.

What each result means

A/A No copy of the version the research linked to LDL cholesterol. This is the starting point the study compared everyone against.
A/T One copy of the version the research linked to LDL cholesterol. That is a smaller link than two copies.
T/T Two copies of the version the research linked to LDL cholesterol. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs62275880

What is rs62275880?

rs62275880 is a single position in the genome, in or near the DOK7 gene. Published research associates it with ldl cholesterol. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs62275880 linked to?

On MyGeneLog this position is linked to Colon Polyp, Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

Does having rs62275880 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs62275880 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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LDL cholesterol (rs62275880). MyGeneLog™. https://www.mygenelog.com/variants/rs62275880

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