0 8125Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others5Total8Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Its strongest genetic-study result is p = 10−9, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 975,353 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.019 lower (95% confidence interval 0.013-0.025); p = 7 × 10−10.
How common The T allele had a frequency of about 96% in the people studied.
Where it sits Chromosome 3, band 3p12.1 — between genes, 209 kb from SRRM1P2.
What each result means
C/CNo copy of the version the research linked to General risk tolerance (MTAG). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to General risk tolerance (MTAG). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to General risk tolerance (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
rs62258408 is a single position in the genome, in or near the CADM2 gene. Published research associates it with general risk tolerance (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs62258408 linked to?
On MyGeneLog this position is linked to Adventurousness. The research behind each link, and its sources, are set out on that condition page.
Does having rs62258408 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs62258408 come from?
GWAS Catalog, Nature genetics 2019, PMID:30643258. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 8125Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others5Total8Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
General risk tolerance (MTAG) (rs62258408). MyGeneLog™. https://www.mygenelog.com/variants/rs62258408