Standard

QRS duration

SCN5A · rs62241190

Where this position leads

Condition: Cardiac Conduction Intervals (PR Interval and QRS Duration)

What the study found

Who was studied 15,124 Hispanic or Latin American individuals.

The effect Each copy of the G allele shifted the measure 2.46 ms higher (95% confidence interval 1.93-2.99); p = 6 × 10⁻²⁰.

How common The G allele had a frequency of about 4% in the people studied.

Where it sits Chromosome 3, band 3p22.2 — in an intron of SCN5A.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of QRS duration — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with QRS duration.

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of QRS duration compared to the general population.

Source

GWAS of QRS duration identifies new loci specific to Hispanic/Latino populations

Swenson BR, Louie T, Lin HJ, Méndez-Giráldez R, Below JE, Laurie CC, Kerr KF, Highland H, Thornton TA, Ryckman KK, Kooperberg C, Soliman EZ

and 18 more — show all

Seyerle AA, Guo X, Taylor KD, Yao J, Heckbert SR, Darbar D, Petty LE, McKnight B, Cheng S, Bello NA, Whitsel EA, Hanis CL, Nalls MA, Evans DS, Rotter JI, Sofer T, Avery CL, Sotoodehnia N

PloS one · 2019 · PMID 31251759 · open access

Questions about rs62241190

What is rs62241190?

rs62241190 is a single position in the genome, in or near the SCN5A gene. Published research associates it with qrs duration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs62241190 linked to?

On MyGeneLog this position is linked to Cardiac Conduction Intervals (PR Interval and QRS Duration). The research behind each link, and its sources, are set out on that condition page.

Does having rs62241190 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs62241190 come from?

GWAS Catalog, PloS one 2019, PMID:31251759. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

QRS duration (rs62241190). MyGeneLog™. https://www.mygenelog.com/variants/rs62241190

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