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Vasculitis (pleiotropy)

near CTLA4 · rs62184865

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻⁸, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 8,467 European, Turkish, Asian or Middle Eastern ancestry cases, 29,795 European, Turkish, Asian or Middle Eastern ancestry controls.

The effect Each copy of the T allele carried 1.72 times the odds of Vasculitis (pleiotropy) (95% confidence interval 1.43-2.08); p = 2 × 10⁻⁸.

Where it sits Chromosome 2, band 2q33.2 — between genes, 29.2 kb from CTLA4.

What each result means

G/G No copy of the version the research linked to Vasculitis (pleiotropy). This is the starting point the study compared everyone against.

G/T One copy of the version the research linked to Vasculitis (pleiotropy). That is a smaller link than two copies.

T/T Two copies of the version the research linked to Vasculitis (pleiotropy). That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Identification of new risk loci shared across systemic vasculitides points towards potential target genes for drug repurposing

Ortiz-Fernández L, Carmona EG, Kerick M, Lyons P, Carmona FD, López Mejías R, Khor CC, Grayson PC, Tombetti E, Jiang L, Direskeneli H, Saruhan-Direskeneli G

and 13 more — show all

Callejas-Rubio JL, Vaglio A, Salvarani C, Hernández-Rodríguez J, Cid MC, Morgan AW, Merkel PA, Burgner D, Smith KG, Gonzalez-Gay MA, Sawalha AH, Martin J, Marquez A

Annals of the rheumatic diseases · 2023 · PMID 36797040 · open access

Questions about rs62184865

What is rs62184865?

rs62184865 is a single position in the genome, in or near the near CTLA4 gene. Published research associates it with vasculitis (pleiotropy). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs62184865 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs62184865 come from?

GWAS Catalog, Annals of the rheumatic diseases 2023, PMID:36797040. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Vasculitis (pleiotropy) (rs62184865). MyGeneLog™. https://www.mygenelog.com/variants/rs62184865

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