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Psoriasis

FLJ16341 · rs62149416

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻¹⁷, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 10,588 European ancestry cases, 22,806 European ancestry controls.

The effect Each copy of the T allele carried 1.17 times the odds of Psoriasis (95% confidence interval -); p = 2 × 10⁻¹⁷.

How common The T allele had a frequency of about 64% in the people studied.

Where it sits Chromosome 2, band 2p16.1 — in an intron of REL-DT.

How common each version is

CT

Korean KRGDB

C 1.6% · T 98.4%

Korean Korea4K

C 2.3% · T 97.7%

Korean Korea1K

C 1.9% · T 98.1%

Japanese ToMMo

C 4.2% · T 95.8%

World gnomAD

C 25.8% · T 74.2%

World 1000 Genomes

C 14.2% · T 85.8%

World TOPMed

C 24.8% · T 75.2%

By ancestry gnomAD

East Asian

C 2.0% · T 98.0%

European (non-Finnish)

C 36.7% · T 63.3%

African / African American

C 11.2% · T 88.8%

South Asian

C 10.4% · T 89.6%

Admixed American (Latino)

C 23.7% · T 76.3%

Middle Eastern

C 28.6% · T 71.4%

Finnish

C 33.5% · T 66.5%

Ashkenazi Jewish

C 29.4% · T 70.6%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study. The ancestry rows are gnomAD's own groups (via Ensembl), as the survey defines them, not races.

What each result means

C/C No copy of the version the research linked to Psoriasis. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Psoriasis. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Psoriasis. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, Capon F, Ding J, Li Y, Tejasvi T, Gudjonsson JE, Kang HM, Allen MH

and 53 more — show all

Collaborative Association Study of Psoriasis (CASP) · Genetic Analysis of Psoriasis Consortium · Psoriasis Association Genetics Extension · Wellcome Trust Case Control Consortium 2

Nature genetics · 2012 · PMID 23143594 · open access

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Psoriasis (rs62149416). MyGeneLog™. https://www.mygenelog.com/variants/rs62149416

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