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Chronotype

ARL14EP · rs621421

Where this position leads

Condition: Sleep and Circadian Rhythm

rs621421 Condition: Sleep and Circadian Rhythm Sleep and Circadian Rhythm Condition rs621421 rs621421 ARL14EP

What the study found

Who was studied 449,734 European ancestry individuals; replicated in 248,098 European ancestry individuals.

The effect The reported allele is C; the catalogue records no effect size ; p = 2 × 10−14.

How common The C allele had a frequency of about 37% in the people studied.

Where it sits Chromosome 11, band 11p14.1 — between genes, 0.1 kb from MPPED2.

What each result means

C/C Two copies of the version the research linked to Chronotype. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Chronotype. That is a smaller link than two copies.
T/T No copy of the version the research linked to Chronotype. This is the starting point the study compared everyone against.
Source
Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms
Jones SE, Lane JM, Wood AR, van Hees VT, Tyrrell J, Beaumont RN, Jeffries AR, Dashti HS, Hillsdon M, Ruth KS, Tuke MA, Yaghootkar H
and 20 more — show all
Sharp SA, Jie Y, Thompson WD, Harrison JW, Dawes A, Byrne EM, Tiemeier H, Allebrandt KV, Bowden J, Ray DW, Freathy RM, Murray A, Mazzotti DR, Gehrman PR, Lawlor DA, Frayling TM, Rutter MK, Hinds DA, Saxena R, Weedon MN
Nature communications · 2019 · PMID 30696823 · open access

Questions about rs621421

What is rs621421?

rs621421 is a single position in the genome, in or near the ARL14EP gene. Published research associates it with chronotype. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs621421 linked to?

On MyGeneLog this position is linked to Sleep and Circadian Rhythm. The research behind each link, and its sources, are set out on that condition page.

Does having rs621421 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs621421 come from?

GWAS Catalog, Nature communications 2019, PMID:30696823. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Chronotype (rs621421). MyGeneLog™. https://www.mygenelog.com/variants/rs621421

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