Standard

Body mass index (adult)

TMEM18 · rs62105306

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 16,559 African ancestry men, 26,193 African ancestry women; replicated in 2,458 African ancestry men, 7,685 African ancestry women, 152,893 European ancestry men, 171,977 European ancestry women.

The effect Each copy of the T allele shifted the measure 0.055 higher (95% confidence interval 0.033-0.077); p = 4 × 10⁻⁷.

How common The T allele had a frequency of about 75% in the people studied.

Where it sits Chromosome 2, band 2p25.3 — between genes, 30.2 kb from TMEM18.

What each result means

C/C No copy of the version the research linked to Body mass index (adult). This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Body mass index (adult). That is a smaller link than two copies.

T/T Two copies of the version the research linked to Body mass index (adult). That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium

Ng MCY, Graff M, Lu Y, Justice AE, Mudgal P, Liu CT, Young K, Yanek LR, Feitosa MF, Wojczynski MK, Rand K, Brody JA

and 101 more — show all

Cade BE, Dimitrov L, Duan Q, Guo X, Lange LA, Nalls MA, Okut H, Tajuddin SM, Tayo BO, Vedantam S, Bradfield JP, Chen G, Chen WM, Chesi A, Irvin MR, Padhukasahasram B, Smith JA, Zheng W, Zheng W, Allison MA, Ambrosone CB, Bandera EV, Bartz TM, Berndt SI, Bernstein L, Blot WJ, Bottinger EP, Carpten J, Chanock SJ, Chen YI, Conti DV, Cooper RS, Fornage M, Freedman BI, Garcia M, Goodman PJ, Hsu YH, Hu J, Huff CD, Ingles SA, John EM, Kittles R, Klein E, Li J, McKnight B, Nayak U, Nemesure B, Ogunniyi A, Olshan A, Press MF, Rohde R, Rybicki BA, Salako B, Sanderson M, Shao Y, Siscovick DS, Stanford JL, Stevens VL, Stram A, Strom SS, Vaidya D, Witte JS, Yao J, Zhu X, Ziegler RG, Zonderman AB, Adeyemo A, Ambs S, Cushman M, Faul JD, Hakonarson H, Levin AM, Nathanson KL, Ware EB, Weir DR, Zhao W, Zhi D, Arnett DK, Grant SFA, Kardia SLR, Oloapde OI, Rao DC, Rotimi CN, Sale MM, Williams LK, Zemel BS, Becker DM, Borecki IB, Evans MK, Harris TB, Hirschhorn JN, Li Y, Patel SR, Psaty BM, Rotter JI, Wilson JG, Bowden DW, Cupples LA, Haiman CA, Loos RJF, North KE

Bone Mineral Density in Childhood Study (BMDCS) Group

PLoS genetics · 2017 · PMID 28430825 · open access

Questions about rs62105306

What is rs62105306?

rs62105306 is a single position in the genome, in or near the TMEM18 gene. Published research associates it with body mass index (adult). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs62105306 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs62105306 come from?

GWAS Catalog, PLoS Genet 2017, PMID:28430825. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Body mass index (adult) (rs62105306). MyGeneLog™. https://www.mygenelog.com/variants/rs62105306

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